Journal article
Smart graphene-cellulose paper for 2D or 3D “origami-inspired” human stem cell support and differentiation
J Li, X Liu, E Tomaskovic-Crook, JM Crook, GG Wallace
Colloids and Surfaces B Biointerfaces | ELSEVIER SCIENCE BV | Published : 2019
Abstract
Graphene-based materials represent advanced platforms for tissue engineering and implantable medical devices. From a clinical standpoint, it is essential that these materials are produced using non-toxic and non-hazardous methods, and have predictable properties and reliable performance under variable physiological conditions; especially when used with a cellular component. Here we describe such a biomaterial, namely smart graphene-cellulose (G-C) paper, and its suitability for traditional planar two-dimensional (2D) or three-dimensional (3D) human cell support, verified by adipose-derived stem cell (ADSC) culture and osteogenic differentiation. G-C paper is prepared using commercially avail..
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Grants
Awarded by Centre of Excellence for Environmental Decisions, Australian Research Council
Funding Acknowledgements
JL, XL, GGW and JMC conceived the study. JL executed the experiments and ETC devised and performed the statistical analyses of data. JL and JMC wrote the paper, with reporting of methods and results of statistical analyses of data provided by ETC. All authors commented on the paper. JMC and GGW are co-senior corresponding authors. The authors wish to acknowledge funding from the Australian Research Council (ARC) Centre of Excellence Scheme (CE140100012), the use of facilities at the University of Wollongong Electron Microscopy Centre, support from the Australian National Fabrication Facility (ANFF)-Materials Node, Dr Patricia Hayes for support with Raman measurements, Dr Dongqi Shi for support with XPS measurements, and Dr Kerry Gilmore for critically reviewing the paper. GGW would like to acknowledge the support of the ARC through an ARC Laureate Fellowship (FL110100196). GGW and XL would like to acknowledge the support of the ARC Industrial Transformation Training Centre in Additive Biomanufacturing (IC160100026).